Switching from OpenLoop or Bask? Free white-glove migration in days.
PharmaBro
  1. Home
  2. Glossary
  3. Testosterone replacement therapy (TRT)
Clinical

Testosterone replacement therapy (TRT)

Also called TRT

Definition

Treatment of clinically low testosterone with prescribed testosterone, which in the United States is a DEA Schedule III controlled substance.

TRT usually means testosterone cypionate by injection, or cream and oral forms, prescribed after baseline labs confirm a clinical indication.

Because testosterone is Schedule III, the workflow differs sharply from most telehealth categories: a synchronous visit before the first prescription, baseline labs, quarterly monitoring, a narrower state map and a higher age floor.

Non-scheduled alternatives such as enclomiphene are prescribable more broadly and can run on asynchronous review with labs, which is how brands cover states where scheduled TRT is unavailable.

Why it matters

TRT cannot be run on a GLP-1 workflow. Labs gate the first fill and quarterly labs gate renewals, and a platform that cannot enforce those gates structurally creates a compliance exposure.

FAQ

Testosterone replacement therapy (TRT), in practice

Scheduled testosterone generally requires a synchronous visit before an initial prescription, alongside baseline labs. Non-scheduled pathways such as enclomiphene can typically run on asynchronous review with labs.